When you have a wound or an infection, inflammation helps fight off germs and facilitates healing. Long-term effects of prolonged "starvation diabetes" is not known of course: it could not last for a long time, otherwise an animal (or human) would die from starvation. We first examined the impact of SR-BI loss of function on autophagy by quantifying the protein levels (Western blotting) of VPS34, Beclin-1, and LC3II in response to different ER stressors, including serum starvation and oxLDL (Figure 1, A and B).Studies have shown … •The Hard Plaque Blunder - Atherosclerosis What You MUST Do To Cure, Prevent And Reverse Heart Disease Quickly •Clear Out Your Arteries Quickly – No Surgery Or Drugs •Eat To Cure, Prevent And Reverse Heart Disease – No Starvation Diets •Control Cholesterol Naturally – No Starvation Diets The explanation offered by the Hazen group is that TMAO suppresses “reverse cholesterol transport” conceived broadly as the process of migrating excess cholesterol out of macrophages for transport to the liver and excretion in feces via the bile. In this respect, glaucoma has much in common with hair loss, Alzheimer's disease, multiple sclerosis, cerebral palsy and hearing problems. The development of atherosclerosis may result in coronary syndromes [], ischaemic strokes [], intermittent claudication [], and aneurysms [], owing to plaque growth and thrombus formation.Low-density lipoprotein cholesterol (LDL-C) and oxidized LDL (oxLDL) [] engulfed by macrophage-derived foam … In the study, middle-aged people with heart disease or diabetes who lost more than 12 pounds over a two-year period successfully reduced the size of the deposits (or plaques) clogging their arteries, rather than merely halting their growth. Cachexia is a syndrome characterized by unintentional weight loss, progressive muscle wasting, and a loss of appetite, and is thought to be directly responsible for 20% of cancer deaths in the United States. A slow, chronic starvation of the brain as we age appears to be a major trigger of a biochemical process that causes some forms of Alzheimer's disease. The regenerative capacities brought by producing the bulk of all energy oxidatively apply more here i.e. Depriving the human body of food activates stress in the body, which results in a cascade of detrimental physiological effects that lead directly to disease and degeneration. A slow, chronic starvation of the brain as we age appears to be a major trigger of a biochemical process that causes some forms of Alzheimer's disease. Increasing attention is now being paid to the important role played by autophagic flux in maintaining normal blood vessel walls. Reversing atherosclerosis with one shot New research demonstrates that injecting synthetically designed nanofibers in mice helps to break up the arterial plaque that is … ... A keto / carnivore eating pattern is reversing / improving atherosclerosis for many who try it. Fasting and low carb can reverse artery-clogging. Although the diet is proven to reverse atherosclerosis, many people find it difficult to stay on this diet long-term; it is very restrictive and does not allow any meat, fish, nuts, seeds or oils. It further postulates that normal … Well, yes, if you look at those living under starvation conditions, there doesn’t seem to be any heart attacks, but that’s not exactly a desirable lifestyle. The 6 Best Supplements and Herbs for Atherosclerosis. Some 79 percent of people age 70 and older have at least one of seven potentially disabling chronic conditions (arthritis, hypertension, heart disease, diabetes, respiratory diseases, stroke, and cancer).7 The burden of such chronic conditions and disability poses a … Understanding the functional role of microRNA-214-3p in atherosclerosis for the identification of novel targeted therapies to prevent or reverse endothelial cell dysfunction and stimulate autophagy. Therefore, the use of such diets for promoting atherosclerosis in these models has been a valuable tool for both gaining more understanding of this disease and testing therapies that can potentially reverse it. Garlic is linked to treating or preventing at least 220 different health conditions or symptoms. The basic rules for preventing atherosclerosis: In the first place is a healthier diet, exercise and weight control. Since these measures normalize and restore blood circulation, prevent stagnation of blood and the accumulation of heavy and harmful fats in it. Peripheral artery disease (PAD) is when arteries in the limbs (usually the legs) develop atherosclerosis. It is a result of low vitamin C and/or high insulin levels, leading to cholesterol and calcium building up in the arteries as plaques. Starvation. First, a well-formulated low-carb diet is moderate in protein — around 1.5 grams per kilo per day. Effects of SR-BI deficiency on macrophage autophagy in response to stress. It's marked by arteries narrowed with and hardened by plaque. The regenerative capacities brought by producing the bulk of all energy oxidatively apply more here i.e. 7. Overweight or obesity. A family history of atherosclerosis or heart disease. In some studies, pomegranate and cocoa have been shown to limit or reverse atherosclerosis, lower high blood pressure, and improve endothelial function in people with the most serious arterial problems, including heart disease and diabetes. The lack of Atg in the whole body or specific tissues in can cause serious disability and death of organisms and this strongly supports the hypothesis that autophagy is an important ... starvation, and hypoxia-ischemia. The Natural Human Diet. It is a risk factor for a broad range of diseases, particularly atherosclerosis and cardiovascular disease. Aggressively lowering cholesterol and blood pressure levels below current targets in adults with type 2 diabetes may help to prevent — and possibly reverse — hardening of the arteries, according to new research supported by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health. ... (Thermo Fisher Scientific). Neither the NHLBI nor the American Heart Association (AHA) goes so far as to recommend a strict vegetarian diet to reverse atherosclerosis, although they both say that less meat in your diet will reduce your risk for heart attack and stroke. Coronary artery disease (CAD), also called coronary heart disease (CHD), ischemic heart disease (IHD), myocardial ischemia, or simply heart disease, involves the reduction of blood flow to the heart muscle due to build-up of plaque (atherosclerosis) in the arteries of the heart. INFLAMMATION AND ATHEROSCLEROSIS Göran K. Hansson, Anna-Karin L. Robertson, and Cecilia Söderberg-Nauclér Annual Review of Pathology: Mechanisms of Disease GENETICS OF ATHEROSCLEROSIS Aldons J. Lusis, Rebecca Mar, and Päivi Pajukanta Annual Review of Genomics and Human Genetics Immune and Inflammatory Mechanisms of Atherosclerosis Quantitative reverse transcription real-time PCR (qRT-PCR) and small RNA transfection were used to explore the miR-542-3p expression in oVSMCs and yVSMCs in vitro. Hardening of the arteries, also known … found that hydroxysafflor yellow a in thp1 macrophages can be combined with ultrasound as a kind of sound … Myocardial fat content refers to the storage of triglyceride droplets within cardiomyocytes, which can be measured in humans by use of proton magnetic resonance spectroscopy (1 H-MRS) ().In addition, the heart and vessels are surrounded by layers of adipose tissue, which is a complex organ composed of adypocytes, stromal cells, … The lack of Atg in the whole body or specific tissues in can cause serious disability and death of organisms and this strongly supports the hypothesis that autophagy is an important ... starvation, and hypoxia-ischemia. To continue reading this article, you must log in. Heart disease is the #1 killer of American women, but there was significantly less clogging in the women eating more whole grains, significantly less progression of their atherosclerosis–in fact, almost as much slowing of their disease as they might get taking cholesterol-lowering statin drugs. Dehydration can cause a build-up of wastes and acids in the body, and it can clog the kidneys with muscle proteins (myoglobin). Atherosclerosis can cause hypertension by reducing vessel contractility & increasing resistance to blood flow. How To Reverse Hardening Of The Arteries (Atherosclerosis) | Dr. Berg | Dr.Berg Blog Hardening of the arteries or atherosclerosis should not be taken for granted, this is why I will show you how to reverse it to rregain your normal heart health. ... while in starvation, the reverse is true and autophagy is active . As a low-carb diet doesn’t need to be very high in protein — for example, 3 grams per kilo per day — the whole “problem” behind this controversy simply does not exist. At least two of them have been called immortal jellyfish. Not only does inflammation cause atherosclerosis, it also accelerates the development of other risk factors for heart disease such as diabetes and high blood pressure. Smoking also induces insulin resistance and causes atherosclerosis. Advertising on our site helps support our mission. Normal TcPO2 at the foot averages about 60 mmHg, but 50 mmHg or greater is considered normal. Starvation as a physiological phenomenon is found in mammals during winter and summer hibernation and during cold torpor in amphibians, insects, fish, and reptiles. 37 Inflammation is part of your body’s immune response to an illness or injury. In the day you can eat 250 g black and 100 g white bread or replace it with grain loaves. Atherosclerosis is a major cause of death worldwide and is the underlying cause of cardiovascular ... such as nutrient starvation, hypoxia, ATP/AMP ratio, intracellular reactive oxygen species (ROS) levels, bacterial and viral infections, and chemical agents. Feeling of heaviness. Definition. LDL is more easily oxidized as the ability of HDL to prevent the oxidation of LDL is diminished. In this study, we examined the effect of myricetin on lipid accumulation in macrophage and atherosclerosis in atherosclerosis-prone low … Atherosclerosis (AS) is a chronic inflammatory disease characterized by abnormal lipid metabolism. Tip Subsequently, question is, can atheroma be removed? Symptoms of cerebral arteriosclerosis include headache, facial pain, and impaired vision. developed a unique diet rich in massive amounts of fruits and vegetables and very low in total calories and fats. After all, you can't see any buildup of waxy plaque that may exist in your arteries, and the disease doesn't make itself known until it's advanced. Till next time. Over time, plaque buildup can lead to … … Healthy lifestyle changes can prevent and even reverse metabolic syndrome. From starvation to obesity and diabetes. Skipping breakfast has been linked with other unhealthy lifestyle habits, such as smoking and excessive alcohol consumption, which could themselves significantly raise a person’s risk for atherosclerosis. Cholesterol efflux is a process whereby cholesterol is excreted from foam cells through transporters, which serves as one of the effective regulatory mechanisms to prevent AS. Some people can reverse atherosclerosis by diet, but others may need medication or surgery to regain healthy arteries. All sufferers of hardened arteries can benefit from following recommended dietary guidelines and incorporating exercise into their daily lives. Managing a moderate weight can lower your risk of developing complications due to atherosclerosis. Physical activity promotes insulin sensitivity and increases glucose uptake by cells. Role of autophagy in macrophages, vascular smooth muscle cells, and endothelial cells in atherosclerosis. Their insight is the basis for a promising therapeutic approach to halt and potentially reverse plaque buildup and the progression of disease, the researchers said. The association of C677T/MTHFR polymorphisms with CAS in the Chinese Han … It is the leading cause of death, as well as the major cause of disability. Be proactive to ward off clogged arteries that can lead to heart attack, stroke, and even death. 7 Simple Ways You Can Unclog Your Arteries Naturally. But when it comes cardiovascular disease, the primary cause of death among people in industrialized countries, garlic is a true superstar ( 5 ). Atherosclerosis is the hardening and clogging of the inner lining (intima) of the arteries with arterial lipid (fatty) deposits and plaque. How To Reverse Clogged Arteries Naturally. There was a study that showed eating healthy and exercising can reverse atherosclerosis. Autophagy literally means “to eat oneself” and originated in Greek. 36 In people with type 1 diabetes, ketone levels over 3.0 mmol/L can be caused by a severe lack of insulin that requires urgent medical attention. The commonly used sphingolipid inhibitors, myriocin (a ceramide inhibitor) and d-PDMP (d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol, a glycosphingolipid inhibitor), have shown therapeutic potential but their efficacy and their … If you have the gumption to make major changes to your lifestyle, you can, indeed, reverse coronary artery disease. Understanding Atherosclerosis. the state of an organism that is completely deprived of food, has an insufficient food intake, or suffers from disturbances in its assimilation of food. 42,43 Atherosclerosis has been shown to be prevented in Il-18 and ApoE double-knockout mice. You can try to: Decrease sugar intake. Methods: ApoE -/- mice were fed on a western diet for 12 weeks to induce atherosclerosis. Quitting smoking benefits your heart and cardiovascular system now and in the future: Twenty minutes after you quit smoking, your heart … The breakages and cracks in the walls of the arteries are observed when there is a deficiency of vitamin C. In such cases, the body is compelled to use cholesterol to patch those bruised arteries. To sum up, atherosclerosis does not have to be the deadly disease it is. They include starvation, fasting, and a low carb ketogenic diet. Complications can include: heart attack, irregular heartbeat, bleeding in brain, hardening of vessels, obstructed or narrowing of major arteries, high blood pressure, oxygen starvation on tissues, and more. In addition to affecting serum lipid levels, inflammation also adversely effects lipoprotein function. Cigarette smoking. The test can be applied equally well in diabetics and non-diabetics. Can We Reverse Atherosclerosis? Lysosomes in atherosclerosis. 2. FACLM on November 15, 2016. In plasma, the concentration of 3-HB could reach ... they have totally reverse effect in the activation of NLRP3 inflammasome. Neufeld T.P. to atherosclerosis than cancer. Caffeine. In the endothelium, a variety of critical triggers ranging from shear stress to circulating blood lipids promote autophagy. The role of FGF21 in atherosclerosis was studied by evaluating its function in apolipoprotein E double knockout (apoE−/−) mice. The plaques cause inflammation and injury, and ultimately, blockages in blood flow. Review the most common poor leg circulation symptoms below. Atherosclerosis is a state where chronic exposure to cellular stressors promotes disease progression and alterations in autophagy is predicted to be consequential. Limit your consumption to one or two drinks a day if you’re a man and one drink a day if you’re a woman. Fasting increases toxins. Difficulty with erections usually means atherosclerosis is developing. One man was quoted as saying he still did not need any diabetes medicines after 18 months. The following tips can help prevent atherosclerosis and improve your general health. Autophagic regulation and dysfunction in atherosclerosis. Not enough exercise. Dr. Pritikin developed this protocol after he was diagnosed with severe atherosclerosis of the coronary arteries. Pawlak K, Domaniewski T, Mysliwiec M, Pawlak D. The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal … Here, we investigated whether empagliflozin, as a kind of SGLT2i, could alleviate atherosclerosis progression in non-diabetic mice. There is one, clinically proven, effective method to not just stop, but reverse, atherosclerosis. Abstract. Take Vitamin K2: K2 is a fat-soluble vitamin that may help reduce calcium. An inactive lifestyle. They say "There were altogether 107 volunteers, 25 to 82 years old (43.6 ± 1.0 years), divided into four age groups; their blood serum samples were analyzed.." but there's no data on what the peoples diets and other markers were like. Furthermore, emerging evidence links … In a cohort study of patients with hyperuricemia, SUA levels were found to be positively correlated with serum TNFα, high-sensitivity CRP (C-reactive protein), and IL-18. Not objective. In 1985, an influential article highlighted in my video The Problem With the Paleo Diet Argument was published proposing that our … 1A, lane 4 vs. lane 1) and presence of bafilomycin A 1 (Baf A1, 20 nmol/L, 60 min), a vacuolar H +-ATPase inhibitor that inhibits autophagosome fusion with lysosomes, 25,26 (Fig. When we age, our arteries harden and thicken because of a build up of fatty material, plaques, and the long term inflammatory immune response which follows. Some of the detrimental effects of fasting include: Fasting inhibits thyroid hormone. Atherosclerosis is considered to be a chronic inflammatory disease that can lead to severe clinically important cardiovascular events. The chemicals you inhale when you smoke cause damage to your heart and blood vessels that makes you more likely to develop atherosclerosis, or plaque buildup in the arteries. There are four particular nutrients you can consume as ways to de-calcify your arteries and potentially reverse clogged atherosclerosis. Atherosclerosis is an important risk factor, but extensive cardiac autopsy studies have suggested that traditional cultures with near-zero heart attack incidence have coronary atherosclerosis (6, 7, 8, 9).Although they tend to have less atherosclerosis than … Cerebral arteriosclerosis is the result of thickening and hardening of the walls of the arteries in the brain. While not everyone is a fan of the pomegranate ’s slightly acidic, yet wonderfully sweet taste, this fruit is masterful at removing plaque buildup according to many studies. With severe arterial occlusive disease TcPO2 is decreased significantly The average TcPO2 at the foot in patients with rest pain or gangrene is about 4 mmHg. Although leptin plays a critical role in the starvation-induced T-cell-mediated immunosuppression, little is known about its role in B-cell homeostasis under starvation conditions. You can start your battle against atherosclerosis by following some simple methods, which include: According to the American Heart Association (AHA), eating a healthy diet and making lifestyle changes can be your two effective weapons in reversing atherosclerosis. Excessive consumption of caffeine can cause your heart to beat irregularly. Cleveland Clinic is a non-profit academic medical center. Coupled with thicker-than-normal blood containing clots, blockage can occur in an artery which stops the flow of blood. We used cells at passages 2–4 after serum starvation for 16 h in DMEM ... A as a reference gene. First, minimize toxicity in your body , then follow a high anti-oxidant diet. Whether or not aging can ever be reversed in humans is still an unanswered question. ... they found that the autophagy induced by starvation was not affected by miR-214-3p modulation, indicating a specific role for miR … Such improvements in diet will not significantly reverse established diabetes or coronary artery disease, but will reduce their rate of progression. You can take Vitamin D3 and even some calcium, especially if you have cramps in your calves (which is a sign of calcium deficiency). 1. Because atherosclerosis is an inflammatory, age-related disease, dietary modification can be an important strategy in preventing atherosclerotic plaque development. Background Uncertainty still remains on the correlation of methylenetetrahydrofolate reductase (MTHFR) variant C677T with risk of carotid atherosclerosis (CAS), and there is a lack of reports on C677T/MTHFR in the Asian population. webmd. london, 30 march 2012: russians born during the leningrad siege in world war ii, which was responsible for some of the greatest losses of civilian life in history, are giving scientists new strategies to identify people who experienced intrauterine growth restriction (iugr) and starvation during childhood at greatest risk of developing long term … We previously identified a mutation in LDL receptor-related protein 6 ( LRP6 ), LRP6R611C, that causes … by DailyHealthPost EditorialJanuary 18, 2020. The keto diet is a low-carb, high-fat diet plan that causes the body to burn fat instead of carbohydrates — a process known as ketosis. The following tips are a few ways to do this. Besides AD, chronic disease and disability can compromise the quality of life for older people. 1) Yoga: A 2013 study showed that a regular yoga and meditation practice significantly reduces early atherosclerosis. For quantitative real-time PCR, we took 5 μl from the reverse transcription, ... HDL can protect against atherosclerosis. 4 Ways To De-Calcify arteries. Written By Michael Greger M.D. The aorta has smaller branches that run to the arms and legs, as well as the rest of the body. Any amount of smoking, even occasional smoking, can cause this damage to the heart and blood vessels. Answer (1 of 9): The same fundamental tenets to creating regenerative healing by facilitating mitochondrial oxidative metabolism apply here. Moreover, there are a number of steps in the reverse cholesterol transport pathway that are adversely affected during inflammation. Eating specific foods cannot cleanse plaques out of the arteries, but a healthful diet can help manage and prevent heart disease. In the nonsenescent human umbilical vein endothelial cells (HUVECs), serum-starvation on its own increased LC3-II levels both in the absence (Fig. Thank for reading. Most men with erectile dysfunction have risk factors for atherosclerosis, including: High cholesterol levels. We do not endorse non-Cleveland Clinic products or services. Malnutrition is a serious condition that occurs when a person’s diet doesn’t contain the right amount of nutrients. It helps to normalize the increased pressure and cleanse the body of cholesterol plaques. studies have demonstrated that sdt has a positive effect on atherosclerosis as it can induce apoptosis of macrophagy in vitro. It is the most common of the cardiovascular diseases. overnutrition – when you get more nutrients than you need. ... atherosclerosis, and tissue fibrosis (La Cava and Matarese ... forward, 5′-AGCCAACGTCAAGCATCTGA-3′ and reverse, 5′-TCGGGTCAATGCACACTTGT-3′; … Food restriction is a promising therapy for many age-associated pathologies as it stimulates the health-supportive mechanism autophagy. A cholesterol-rich diet can aggravate atherosclerosis in apoE −/ ... 3-HB is an endogenous molecule produced via fatty acid β-oxidation during starvation or intense exercise. (a) Oxidized lipids (e.g., oxLDL and 7-ketocholesterol) present in atherosclerotic plaques can stimulate autophagy in macrophages (MΦ) in either a direct manner or indirectly through induction of ER stress.Degradation of damaged … This is said to help with weight loss. 23 similarly, it can effectively stabilize the atherosclerosis plaque of the thigh artery in mice. Medically reviewed by Gerhard Whitworth, R.N. In stage and tissue experiments, and for hormone regulation and starvation conditions, the reverse transcription reaction total was 50 μl. You may feel hungry constantly over time. Fasting inhibits detoxification. Of course, aging can be reversed – the immortal jellyfish. This is a myth based on two misunderstandings. All these things can hurt the kidneys. The starvation diet lasted two months, after which, “The volunteers were returned to eating normally but had received advice on portion size and healthy eating.”. Abstract. I have read that people who have suffered from prolonged starvation end up with no plaque left in their blood vessels. Atherosclerosis (AS), a typical chronic inflammatory vascular disease, is the main pathological basis of ischemic cardio/cerebrovascular disease (CVD). Atherosclerosis appears to have a penchant for the vessels of the heart, but it is also common to have atherosclerosis of the vessels of the brain (which can lead to stroke), the vessels of the kidneys (leading to stenosis of the renal arteries), and the vessels of the neck (which can lead to stroke). 2009; 204:561–566. ... coronary artery disease is reversible comes from autopsies performed on people who lived through prolonged periods of starvation during World War II. Numbness or tingling in the leg. This condition can occur in a few parts of the body. Drug or alcohol abuse can potentially cause serious health issues for the heart and cardiovascular system. PDGF signaling is a key mediator of SMC proliferation, but the mechanisms that control its activity remain unclear. ... Then suddenly it was noted that a heart attack and other complications of atherosclerosis of the vessels of the body became more common. However, there are some species of animals in the phylum Cnidaria that can and do reverse aging in themselves 19,20. Atherosclerosis is a chronic inflammatory disease that can cause acute cardiovascular events. Malnutrition means “poor nutrition” and can refer to: undernutrition – when you don’t get enough nutrients. Our epidemics of dietary disease have prompted a great deal of research into what humans are meant to eat for optimal health. Cerebral arteriosclerosis can cause serious health problems. Figure 2: Concentrations of ketone bodies and plasma free fatty acids (FFA) in transition from the postabsorptive state to 4–6 weeks of starvation in a large number of subjects, male and female. There are things we can do to stop it an reverse it. Pomegranates. Recently, scientists might have succeeded turning the time back for people suffering from atherosclerosis. Aggressive cholesterol-lowering drugs like Crestor (potent member of the statins) have proved not to only lower your LDL or bad cholesterol levels, but really reversing atherosclerosis impact on your cardiac system. The science suggests that, if you can do it, a prolonged fast for 2-3 days will induce your body to clean out some old immune cells and switch on production of new ones. 20-40% reduction in calorie intake over a long period of time (1200 calories for women vs 1400 calories for men per day) Intermittent Calorie Restriction. The more important point is that atherosclerosis does not equal heart attack. Starvation began to be scientifically studied in the 19th century. Definition. The Ornish claims are based on a study he performed between 1986 and 1992 which originally had 28 patients with coronary artery disease in an experimental arm and … Erectile dysfunction can also mean atherosclerosis is already present, in the arteries of the heart or brain. starvation, sodium toxicity and waste accumulation. The juices are rich in proteins, which then split up into amino acids in the intestine. Smoking is a major risk factor for heart disease. The benefits of a calorie restriction diet are profound when it comes to improving health and longevity. Types include stable angina, … Garlic. Long-term administration was characterized with low efficacy and serious side effects, while the macrophages with attractive intrinsic homing target have great potential in the efficient … The fact is that the incidence of heart attacks increased very rapidly between the beginning of the 20th century and 1970. What is Malnutrition? Near the heart, atherosclerosis develops. So, here’s my protocol for reversing atherosclerosis or hardening of the arteries: Get your Vitamin C from vegetables Take Vitamin K2 Heal the original problem. The obesity paradox is a medical hypothesis which holds that obesity (and high cholesterol, when the more global term "reverse epidemiology" is used) may, counterintuitively, be protective and associated with greater survival in certain groups of people, such as very elderly individuals or those with certain chronic diseases. Calories per day still did not need any diabetes medicines after 18.... Fatty acid oxidation [ 7, 8 ] & fclid=490957c0-d98a-11ec-b88f-f5ef4e30d453 & u=a1aHR0cHM6Ly93d3cud2VzdG9uYXByaWNlLm9yZy9oZWFsdGgtdG9waWNzL2NvZW56eW1lLXExMC1mb3ItaGVhbHRoeS1oZWFydHMv & ntb=1 '' > Fasting and low can! 220 different health conditions or symptoms atherosclerosis < /a > from starvation obesity. Low in total calories and fats affected during inflammation > obesity paradox < /a > Introduction is inflammatory... 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can starvation reverse atherosclerosis